00:00 Introductions and instructions
02:04 Presenting Nicola Bagalà
03:04 How did a young Nicola get interested in questions about ageing?
04:50 Other aspects of Nicola’s life
06:15 Typical ways we look at the last decades of life and how do you see them, Nicola: “Nobody ever died because they were too healthy.”
08:40 Pacemaker cells? “Running out of cells” is a common way of ageing. And ageing ITSELF is a sort of disease, depending on definitions. More accurately we might consider ageing as a set of diseases.
11:20 The processes that lead to , i.e, Alzheimers or cancer or essentially the same as those “diseases” themselves. At younger ages, these processes are not yet pathological in their expression
13:05 So, if we could control these disease processes, could we, say, live forever? Well, that depends, Nicola replies. But the point of rejuvenation is not eternal life but good health.
15:52 What technology? Some clarification to begin with, like metabolism. There are 7-9 areas of accumulative damage which we may be able to treat area by area. A series of different therapies.
19:27 Heidi asks about “inner technologies” which are not included in the conversation so far (Ken Wilber’s left side quadrants). Nicola asks for clarification
22:50 He sees the “left side” as still part of what affects the objective approaches he describes.
24:29 He describes some of the anti-ageing therapies. But they’re not available yet! He relates the cumulative effects of multiple therapies that will still takes decades to become available, for our children and theirs
29:20 Currently promising therapies: senolytics which i finding ways to search out and remove senescent cells so that natural immunities will function better because the cells are more healthy.
33:20 Mark reports on a personal experience with healing, concluding that he must have the “proper” proportion of senescent cells. Ha-ha! And Nicola integrates the experience into his understanding of healing and now back to senolytics.
35:00 Interesting results in mice, human trials may be soon. A comment from a watcher who notes some caution necessary, perhaps an autoimmune problem?
37:57 Lifespan.io and the Life Extension Advocacy Foundation (LEAF) for more info about fine tuning how this targeting works. LEAF is an American charity for raising funding for ageing research
40:35 Ageing is not a very popular topic! Also some technical experimentation by us!
42:05 What about telomeres? Telomeres are structures on the ends of chromosomes which “wear out” with age and normal cell division leading to a critical shortness so that they no longer allow for further division, hence ageing. But they allow all cells to continue to divide, including cancerous ones which take special advantage of the telomerase enzyme to grow vigorously.
43:40 Aubrey de Grey of the SENS Foundation could avoid the telomere problem with the infusion of stem cells! Another program called ALT (Alternative Lengthening of Telomeres) is underway to understand how cancers use this means to propagate.
46:47 Watchers’ questions: What does your guest say is the definition of life? Nicola’s response is interesting! Age may be a factor in an unexpected way! A spirited discussion follows! Nicola insists that the central issue is not age, per se, but HEALTH!
53:14 Marks so far unasked question, “What the hell is society going to do with all these old people collecting Social Security and old age pensions, etc?” Nicola has thought about this!
57:00 Reactions from watchers. Is coconut oil important for Alzheimer’s? No info from Nicola.
58:40 Last remarks from Nicola: Being sick is not fun. Getting sick is much more probable as we age so let’s begin working on
59:43 Thank you’s and goodbye’s and upcoming shows.
#CrowdfundTheCure for #aging at www.lifespan.io
A TedTalk by Aubrey de Grey: https://www.ted.com/talks/aubrey_de_grey_says_we_can_avoid_aging/up-next
A recent article by Nicolà Bagalà: http://transhumanist-party.org/2017/10/17/the-good-sides-of-aging/
Nicola Bagalà is on Facebook in Italian: https://www.facebook.com/nicola.bagala
Also in English on Facebook: Rejuvenaction